Answsering law quesiton Essay Example | Topics and Well Written Essays - 1000 words

Answsering law quesiton - Essay Example Jaime owed Simon and Davina a duty of care, being the owner of a restaurant which serves food to the public for a fee. Hence, he has the duty and obligation to see to it that clients are served well because he is engaged in the food business, and attached to this is the quality of service to his clients. Based on the facts of the case, there is clearly a breach of duty on the part of Jaime, the moment he forget to inform the chef that Simon and his guest only requested for vegetarian dishes. It was due to the fact that there were several guests that same night that kept him pre-occupied that he totally forgot to inform the chef of Simon’s request. As a restaurant owner, he owed a duty of care to all the clients and guests who enter and dine in his restaurant. In the case at bar, the fact that Simon informed Jaime only to serve them vegetarian dishes is an indication that Simon has already foreseen the damage or harm that will be inflicted upon Davina in case a different food, and not vegetarian dishes will be served to her. This act done by Simon in order to protect Davina is also known as the ‘neighbor principle’. He took the necessary steps to exert reasonable amount of care to avoid acts or omissions which you can reasonably foresee would be likely to injure his guest, Davina. It is thereof without a doubt that a duty of care was expected of Jaime to Simon and Lavina There is also a proximity between the parties, as Jaime is the seller and Lavina and Simon are the buyers of his services. Under the law, is it fair, just and reasonable in all the circumstances to impose a duty of care in the case of Jamie. Here, Jamie is liable for the tort of negligence due to his failure to exercise reasonable care which caused a damage to Davina. His failure to inform the chef that only vegetarian dishes should be served is tantamount to negligence or omission on the part of Jamie. Therefore, he is liable to pay consequential damages to Davina because th ere is a strong connection between the cause of his failure to take reasonable care and that damages that Davina has suffered. Verily, there is a clear showing that Davina would not have been injured â€Å" but for† the Jamie’s act or omission. Hence, Davina entitled to an award of consequential damage because aside from the violent illnsess, she also suffered from consequential economic loss when she cancelled a photo shoot costs of the damage for a beauty campaign, which could have been an opportunity for her to receive economic gain. 2.) Jamie can raise the defense of contributory negligence on the part of Davina. This means that any award of damages may be reduced to the extent that the Davina, the claimant was to blame for the injury or loss inflicted to herslf. It is entirely Davina’s fault if she had too many glasses of champagne prior to her meeting with Simon and totally forgot to inform him about her allergic food reaction. This act shall hold her liab le for contributory negligence. The fault shall be shared by Jamie and Davina. There was also a mistake committed by Davina by coming to the restaurant in a sober mood, and totally disregarding to report to Simon about the allergic food reaction that she possesses. This act redounds to inaction, omission and oversight on the part of Divina. The Law Reform Act 1945(Contributory Negligence) provides for apportionment of blame between the

Designing lesson plan Essay Example for Free

Designing lesson plan Essay Introduction A. Background To achieve the Content Standard (Standar Isi) in the curriculum which covers the Competency Standard (Standar Kompetensi (SK)) and the Basic Competency (Kompetensi Dasar(KD)), students should go through the teaching and learning process. Educational Ministry Regulation number 41, the year of 2007 about the Process Standard states that every school teacher should make Lesson Plans (Rencana Pelaksanaan Pembelajaran(RPP)) to foster the teaching and learning process to be interactive, inspirative, joyful, challenging, motivating the students to participate actively, and giving enough opportunities to them to be innovative, creative and self reliance according to their talents, motivations, and physical as well as psychological development. Through out this module, the important elements of a lesson plan will be discussed. You are supposed to be able to implement your knowledge concerning language teaching and learning such as language competency, methodology and approaches to foreign language learning, media and learning resources, and language assessment in developing lesson plans. By completing of every parts presented in this module you will be able to design lesson plans which can fulfill the required process standard mentioned above. B. Objective Through the elaborations and the discussions of important factors and elements in lesson planning, you will be prepared to be able to carry out the teaching and learning process as requested by the new curriculum (KTSP) C. Indicators After completing this module you are supposed to be able to : 1. state the important elements of lesson planning. 2. determine the indicators of achieving the basic competencies 3. formulate the objectives of the teaching and learning 4. select relevant learning materials 5. plan the stages of teaching and learning activities 6. assess the students achievements DESIGNING LESSON PLAN A. The Concept of Lesson Plan Activity 1 Instructions : Think about these three questions Discuss them; how they relate to the lesson planning A lesson plan is a teachers detailed description of the course of instruction for an individual lesson. (Wikipedia, accessed on the 6th of September 2009). The government regulation No. 19, the year of 2005 states that the planning for instructional process covers the sylabus and the lesson plan containing the purpose, learning materials, methodology, the learning resources and the evaluation. Those are the components of a lesson plan. But by the discussion you have just done, we may conclude that those components could be summarized into three important aspects; the purpose of the instruction (question 1), the learning activity (question2), and the feedback or evaluation (question3). Based on the ministry regulation, number 41, year 2007, the process standard, it was explained that a Lesson plan is the elaboration of syllabus which illustrates the teaching and learning activities to achieve the goals of the basic competency. Every teacher who uses school curriculum, should design a plan completely and systematically to make the teaching and learning interactive, inspirative, joyful, challenging, and be able to motivate students to be active, creative, and self reliance, in line with their talent, motivation, their physical and psychological development. This statement is mostly about the teaching and learning activities. Every stage of the lesson should be planned to fulfill the above requirements and make certain that the instructional objectives could be achieved. B. The components of a Lesson Plan Activity 2 Instructions : Share your experiences with your friends for the lesson plans you have ever made. Which components do you think is the most difficult to write? A Lesson plan is designed to meet the basic competencies, which can be carried out in one meeting or more. Things that should be written in the lesson plan are as follows: 1. Identity of the subject matter which consists of; a. Title of the lesson b. Class/ Semester c. Program (especially for Senior High) d. Theme e. Time allotment 2. Competency Standard Competency Standard is the qualification of the students’ minimal ability, which illustrates the mastery of knowledge, attitude, and skill obtained through each class or semester for every subject. 3. Basic Competency Basic competency is a sum of students’ ability for certain subjects as the reference for determining the indicators for competency achievement in a subject. 4. Indicator for competency achievement The measurable or observable behavior, which shows the achievement of specific basic competency as the reference for the subject evaluation. The indicators for competency achievement are formulated with operational verbs that can be measured which cover the knowledge, attitude, and skills. 5. The Instructional goal Instructional goal illustrates the process and the learning outcome achieved by the students in accordance to the basic competency 6. Instructional material It includes the fact, concept, principle, and the relevant procedure, and written as suitable items in relation to the indicators for competency achievement. 7. Time allotment Time is allocated as much as needed to achieve the Basic competency and the learning load. 8. Methodology Methods are used by teachers to create the teaching and learning process to enable the students to achieve the basic competency or a set of specified indicators. The choice of methods should consider the students’ situation and condition as well as the characteristics of every indicators and the competency which will be achieved in every subjects. 9. Learning activities a) Pre- activity This activity is done at the beginning of the lesson and meant for arousing the students’ motivation and to focuss the students’ attention as well, so that they can particà ­pate actively during the lesson. b) Whilst activity This is the main learning process and aimed at achieving the basic competency. This activity is conducted interactively, inspiratively, joyfully, chalenging, motivating the students to participate actively, and giving opportunities to the students to have innovation, creativity, and selfreliance in accordance to their talent, motivation, physical and psychological development. This activity is conducted systematically through exploration, elaboration, and conformation processes. c) Post activity This activity is done to end the lesson which can be in the form of summarizing, evaluation, reflection, feedback , and follow up activities. Stages of Learning Activity : 10. Evaluation The procedure and the instruments for assessment should be based on the indicators for competency achievement and refer to the evaluation standard 11. Learning Resource Selecting the learning resource should concider the competency standard and the basic competency, as well as the learning material, the teaching and learning activities and also the indicators for competency achievement. C. The Principles of Designing Lesson Plan Activity 3 Instructions : Take any English lesson plan you have had. Try to make a judgment for this (excellent, good, or poor) What criteria do you take for consideration? a. Individual differences Consider the individual differences concerning students’ level of mastery, interest, motivation, potential, emotion, learning style, special need, learning speed, socio cultural background, values, and living environment. b. Fostering students’ participation The lesson should be students-focus and fostering, crea ­tivity, initiative, inspiration, self reliance, and learning motivation. c. Developing students’ reading and writing habits Teaching and learning should develop students’ reading habits on various resources and their ability to express feelings and opinions in different forms of writing. d. Giving feedback and follow up A lesson plan should include activities which can give positive feedback, reinforcement, enrichment, and remedial. e. Link and Unity Lesson plan is designed considering the links and the unity among the competency standard, basic competency, learning material, instructional activities, and indicators for competency achievement, evaluation, and learning resources. Lesson plan should accommodate the thematic instructions, links with other subjects, across the learning aspects, and cultural diversity. f. Employing the information and communication technology Lesson plan is written to foster the use of information and communication technology, integrated, systematic, and effective depending on the situation and condition. D. The Stages of Developing a Lesson Plan A well developed lesson plan reflects interests and needs of students. It incorporates best practices for the educational field. (Skowron, Janice.2006). In Indonesian schooling, the Curriculum of School Level (KTSP) has already been set up by the content standard (SK) and the graduation standard (SKL). Therefore students should be able to achieve what so called the minimum requirements which have been stated in those two documents. The students’ interest relates to the learning materials and depends on how the learning activity is conducted. Therefore you must employ various kinds of methods and approaches. The use of teaching aids and media may also be inspiring and increasing the students’ motivation. According to the process standard (Educational Ministry Regulation no.41, the year of 2007) a lesson plan is a unit plan which covers one basic competency and the time span may be more than one meeting. But the English curriculum and syllabus developed in the content standard are directed to follow the two cycles (oral and written), and the four stages (building  knowledge of the field, model of the text, joint construction, and independent construction). Therefore, English lesson plans should be integrated units which may cover more than one single basic competency; listening and speaking for the oral cycle, reading and writing for the written cycle. Integrating all the four basic skills will also be possible. Here are the stages of designing an English Lesson Plan : Mapping the Competency Standard and the Basic Competency Determining the indicators for basic competency achievement Setting up the Purpose Selecting the Learning Material Structuring the stages of instruction Preparing the assessment The flow of a lesson development : 1. Mapping the Competency Standard and the Basic Competency This stage is ideally done when designing the syllabus. The Competency Standard and the Basic Competency which can directly picked up from the documents are to be analyzed and put into units. English or language in general has special characteristics which might be different from other subjects. The competency based curriculum developed in the content standard is prepared to teach students the communicative competency which covers the actional competence, linguistic competence, socio cultural competence, and strategic competence. The competencies are interrelated to each other and the core of those four competencies is the discourse competence. (Kurikulum Berbasis Kompetensi, Bahasa Inggris, 2004) Diagram 5: Model Kompetensi Komunikatif (Celce-Murcia et al. 1995:10) In general, there four Competency Standards; Listening, Speaking, Reading, and Writing which are states in the documents of content standard (SI), attachment for English subject. Your task is to select the basic competencies which can be combined into unit plans considering the suggested aproach in designing the stages of instruction (four stages in two cycles). Here is examples of mapping the basic competencies : Class VII/ Semester 1 SK 1 dan 3. KD Listening 1.1 dan KD Speaking 3.1 3.2 Merespon makna , melakukan : Tindak tutur : Menyapa orang yang belum/sudah dikenal Memperkenalkan diri sendiri/orang lain Memerintah atau melarang Class IX/ Semester 1 SK 5 dan 6 KD Reading 5.3 dan KD Writing 6.2 Merespon makna dan langkah retorika dan Mengungkapkan makna dan langkah retorika: monolog descriptive dan recount 2. Determining the indicators for basic competency achievement. Indicators reflect measurable or observable behavior to show the achievement for the basic competency which will be used as the reference of the assessment. Indicators for achievement should be written by using operational verbs covering the knowledge, attitude, and skills. i.e. : knowledge : mentioning, interpreting, defining, completing, summarizing, explaining, developing, etc. attitude : participating, adjusting, helping, proposing, serving, inspiring, etc. skill : expressing, practicing, fixing, arranging, demonstrating, etc. 3. Setting up the Purpose Educational Ministry Regulation No. 41, about the Process Standard states that the Purpose of Instruction describes the process and the learning outcome expected to be achieved by the students referring to the basic competency. (Tujuan pembelajaran menggambarkan proses dan ha ­sil belajar yang diharapkan dicapai oleh peserta didik sesuai dengan kompetensi dasar). The two aspects you have to include in setting up the purpose are : a.The process It reflects the expected students activities during the lesson. The activities should student centered. The more students involved through out the lesson would be the better. Consider the students’ motivation, interest, challenge, and creativity. i.e. Listening : minimal pair, sound identificatifying, gap-filling, predicting, comprehending etc. Speaking : interactive communication activities, role playing, scenario, speech, debating, interviewing, dialogue, etc. Reading : scanning, skimming, reading intensively, predicting, classifying, etc. Writing : co-operative writing, drafting, analyzing, guided writing, programming, listing, revising, reviewing, giving comments, summarizing, etc. b.The learning outcome It refers to the achievement of the basic competencies covering the knowledge, attitude, and skills. i.e. : responding meaning to different kinds of text type. expressing meaning for different kinds of purposes pronouncing, reading aloud etc. 4. Selecting Learning Material The learning materials prepared for the lesson plan should be based on the students’ literacy level; performative, functional, or informative. The latest is meant for high school. In performative level, students are taught how to use English to accompany actions, participate in classroom and school interactions, and recognize simple written English. While in the functional level students are supposed to learn to use English to get things done, for  survival purposes (buying and selling, asking and giving permission, making and canceling appointments, read and write simple texts, read popular science, etc.) You have to remember that our English curriculum is text based. Therefore we have to select the material according to the suggested text type. For junior high school are descriptive, procedure, recount, narrative, and report. While news item, discussion, explanation, exposition, and review are for senior high school. There are various resources where we can get the learning materials. Any learning material will be applicable as long as they can meet the curriculum requirement of teaching the students for communicative purposes. They might be presented in all types of communication, transactional conversation, Interpersonal conversation, Informational texts (spoken and written) in the daily life context. For example : Transactional conversation : giving directions in various contexts (kitchen, street etc.) Interpersonal conversation : talking about how to do things casually for the sake of maintaining conversation 5. Structuring the stages of instruction The lesson is carried out through three phases; Pre-activity, Whilst-activity, and Post-activity. a. Pre- activity  This activity is done at the beginning of the lesson and meant for arousing the students’ motivation and to focus the students’ attention as well, so that they can participate actively during the lesson. b. Whilst activity This is the main learning process and aimed at achieving the basic competency. This is suggested to follow the two-cycle approach (oral and written) and the four stages of lesson development; Building Knowledge of the Field (BKOF), Modeling of the Text (MOT), Joint Construction of the Text (JCOT), and Independent Construction of the Text (ICOT). This approach is in line with the flow of a lesson mentioned in the process standard;  exploration, elaboration, and confirmation. Exploration = BKOF Elaboration = MOT Confirmation = JCOT, and ICOT c. Post activity This activity is done to end the lesson which can be in the form of summarizing, evaluation, reflection, feedback, and follow up activities. 5. Preparing the assessment Assessment is a method of evaluating student performance and attainment, Microsoft ® Encarta ® 2009. This stage focuses on ensuring that your students have arrived at their intended destination and has been formulated as the indicators for competency achievement. For this, you will need to gather some evidence that they have done. You usually can do by gathering students work and assessing this work using some kind of grading rubric that is based on the indicators. You could also give test to the students on various domains as well. Here are what we have to assess : Communication that happens in texts Students’ ability to create and respond to texts In listening, speaking, reading, and writing The texts that we may use : Spoken : Informational texts -Transactional and interpersonal dialogues Monologues in the target genres Written : Informational texts Essays in the target genres Test items should not measure the students’ knowledge on the rules of the language. Instead they should be focus on meanings. The meanings tested are : Ideational meaning (isi berita) Interpersonal meaning (tujuan text, tindak tutur) -Textual meaning (termasuk punctuation) Logical meaning (hubungan logis antar gagasan) 6. An Example of a Lesson Plan Engish Version : SMP/MTs: †¦. Subject : English language Class/Semester : VII (Seven) / 1 Text types : Transactional / Interpersonal Theme : Personal Life Skill : Listening Time allotment : 2 x 40 minutes Competency Standard : 1. To understand the meaning of transactional and interpersonal dialogues to interact with the closest environment. Basic Competencies : 1.1. To response the meaning in the transactional ( to get things done) and interpersonal dialogue which is used in the simple oral communication accurately, fluently, understandable to interact with the closest environment that involves: greeting people/ friends, self introduction, others, ordering and forbidding somebody. To ask and to forbid. Greeting strangers / familiar people Introducing selves and other people Ordering / forbidding Indicators for Achievement : The students are able to: a. response the expression of hello from the strangers b. response the expression of self introduction. c. response the expressions of other people’s introductions. d. response the comment expression. e. response forbid expression. f. response the expression of hello from the familiar people Purpose : Through modeling and interactive activities, students can conduct simple communication in the transactional and interpersonal dialogues. Learning Materials: Dialogues that uses the following expressions : 1. A : Good morning. How are you ? B : Good morning. Fine thank you. 2. A : Hello, I’m Nina. Nice to meet you B : Hello, I’m Renny. Nice to meet you, too 3. A : Don’t do that ! B : No, I won’t. Don’t worry 4. A : Stop it ! B : Ok Vocabularies related to text-type and theme, e.g : name, live, address, etc. Verbs : live, meet, do, stop, have To be : is, am, are Personal Pronouns : I, you, we, they, he, she, it Standard expression : Good morning Don’t worry Thanks Nice to meet you OK How are you ? a. Teaching method/ Strategy : Three-phase technique A. Pre- activities Question and answer about things related to students’ life Students answer the questions of personnal identity B. Whilst activities 1. To discuss new vocabulary of the texts 2. To listen some sentences of teachers models 3. To guess the meaning and function of sentences produced by teachers 4. To immitate some sentences of teachers’ pornounciation 5. To listen to the dialogue of introductions 6. To answer the question of the content of the dialogue. 7. To response to the expressions of greeting, introduction, command, and prohibition. 8. To act out the teacher’s commands. C. Post-activities 1. To ask the students’ difficulties in learning activities. 2. To summarize the learning materials. 3. To give students some tasks of using expressions in the real situation Learning Resources The relevant text book : ( title, author, publisher, year, page ) Script of dialogues or dialogue recording The relevant pictures Evaluation Technique: Responding to the expressions / questions orally and written . Forms : oral questions Test Items : Part I : Listen to the expressions and give your response orally Good morning. How are you? †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. Hi, I’m Reno and you are? †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. Are you Anisa? †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. Hello, it’s nice to meet you †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. Who is that girl? †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. Part II : Listen to the expressions and choose the best response, a, b, c or d. 1. A: Hello, how are you ? B : †¦ a. Fine, thanks b. I’m Renny c. Thank you d. Don’t worry 2. A: Is that your sister, Anna ? B : †¦ a. Yes, it is b. No, she’s not here c. I don’t know d. Very well, thanks. 3. A: Budi, this is my friend, Susan. B : Hi, Susan †¦ a. Fine, thanks. b. It’s Ok c. Nice to see you d. I’m alright 4. A: Open the door ! B : †¦ a. OK b. Fine b. Fine c. Good d. Really 5. A: Don’t be late to school. B : †¦ a. Yes, Sir b. No, Sir c. Ok, Sir d. Fine, Sir Scoring guide: 1. For part I, each correct item is scored 3 2. For part II, each correct item is scored 2 3. Total Score Part I : 5 x 3 = 15 Part II : 5 x 2 = 10 TOTAL : 25 4. Maximal score = 10 5. Students’ score = Rubrics for Part I: No. Uraian Skor I Content and grammar are correct The content is correct, grammar is wrong Content and grammar are not correct No answer 3 2 1 0 II For every correct answer For every wrong answer/ no answera 2 0 Approved by : School Principal English Teacher . RESOURCES FOR LESSON PLAN IDEAS ON THE INTERNET PBS TeacherSource A large collection of lesson plans, teacher guides, and online student activities correlated to 90 sets of state and national curriculum standards. http://www.pbs.org/teachersource/ Best of Education World ® 2002 http://www.education-world.com/best_of/2002/ Education World ® Lesson Planning Center http://www.education-world.com/a_lesson/ Education World ® National Standards http://www.education-world.com/standards/national/index.s

Human Nature and Moral Theory in Plato’s Republic Essay -- Plato Repub

Human Nature and Moral Theory in Plato’s Republic In Chapter 2 of Republic, Glaucon uses the Myth of the Lydian Shepherd to portray a pessimistic view of human nature. Plato, the author of Republic, uses his brother Glaucon to tell the Myth of the Lydian Shepherd. We are led to believe that Plato takes the myth and its implications on human nature very seriously by use of a personal character. The argument, originally given by Thrasymachus, contends that at the root of our human nature we all yearn for the most profit possible. It also contends that any man will act immorally if given free reign. The theory proves unplausible due to circularity in the argument and implications that prove untrue. Thrasymachus approaches Socrates, the main character of Republic and most of Plato's work, during a conversation on the topic of morality. The aggressive Thrasymachus interjects his own opinion; morality is "the advantage of the stronger." (Republic 338c) Upon clarification, Thrasymachus lays out his view of socially created moral relativism, as opposed to Socrates' moral objectivism. Thrasymachus illustrates his view by citing how different types of government create laws serving purposes specific to each government, "a democracy passing democratic laws, a dictatorship making dictatorial laws†¦ In doing so each government makes it clear that what is right and moral for its subjects is what is to its own advantage." (Republic 338e) Thrasymachus also argues that it is advantageous to live an immoral life rather than a moral one. He says, "morality and right are actually good for someone else†¦ and bad for the underling at the receiving end of the orders†¦ the opposit e is true for immorality: the wrongdoer lords it over those ... ...l men desire power and superiority. However this argument raises inconsistencies because Thrasymachus' Argument implies that every person in power attained that position motivated by the desire to commit large-scale immoral actions. The Collapse Argument shows that the implications of Thrasymachus' Argument lead to an inevitable social collapse. Since not all societies have collapsed, some other motivation must have impelled individuals to seek positions of power. In addition, Thrasymachus could not adequately support the second premise of his argument without a defense that leads both Premise 2 and conclusion C to circularity. Thus the argument presented by Thrasymachus and Glaucon is implausible, and the moral relativism that emerges from their line of reasoning is not proven. Work Cited Bloom, Allan. The Republic of Plato, New York: Basic Books, 1968.

Waiting for an Angel By Helon Habila

Helon Habila is a poet and a prose writer who grew up in Gombe, Nigeria. When he was a boy, it was the time when Gombe was recovering from a civil war. His father, who used to work at the Nigerian Ministry of Works, dreamed Habila to be an engineer. But he gave up that dream when he began giving Habila some romance literature and Arabic classics. Instead of concentrating on Nigeria, Habila spent most of his time traveling in different places. He also had read great books from famous Nigerian writers like Chinua Achebe and Ben Okri.While reading books, Habila also learned the mastery of story telling. In his primary school, his teacher noticed his talent and asked him to tell stories in other classes. After secondary school, Habila took a degree in engineering at Bauchi University of Technology in Nigeria. But after a year, he dropped out and shifted to College of Arts and Science. However, he still did not become satisfied and quit school permanently. Habila found his life going nowh ere when he got a copy of a novel by E. M. Forster, the Aspects of the Novel. This novel took him back to his passion for literature.He then spent his time in his room reading and writing. During the period he was starting his new life, his father and his brother died in an accident. This time, he entered again another university to study English and Literature. Finally, he succeeded. For two years, he became an assistant lecturer at Federal Polytechnic at Bauchi. During his stay there, he had written two literary pieces, a biography of a chief and a rough copy of a novel entitled â€Å"Prison Stories†. It was all about entwined stories of a young journalist during the regime of General Abacha.When the democracy was regained in Nigeria, Habila pursues his writing career. By the year 2000, he had already won two big awards: the MuSon Poetry Festival Prize for his â€Å"Another Age† and Liberty Bank Prize for â€Å"The Butterfly and the Artist†. Habila also won th e Commonwealth Writers Prize last 2003 for his novel Waiting for an Angel. His latest novel as of today is the Measuring Time (Bures). The Setting The setting of the novel â€Å"Waiting for an Angel† is in Nigeria during 1990s. During this era, the state was dominated and ruled by sadistic brutality.Also, violence on human rights is very prevalent in the country. Nigeria was barred from Commonwealth of Nations. Additionally, almost all countries have charges against Nigeria. This was the situation when the novel took place. The military or dictatorial government of General Sani Abacha eradicated the critical thinking of the countries’ gifted writers and scholars (Whipple). The Characters The main character of the story is Lomba. He is a journalist and an aggravated novelist who was in prison during the first part of the chapter. He writes poems secretly during his incarceration.His roommate, Bola, loses sanity after his family died. Bola also experienced brutality from the hands of the police officers. Mauftu is a superintendent in Lomba’s prison. When he found out the love poems written by Lomba, the jailer asked him to write verses for the girl he was courting, Janice. Janice is a teacher being pleaded by Lomba to save him. However, the teacher cannot save him even she knows Lomba’s troubles. James Fiki is the editor of â€Å"The Dial†, the publication where Lomba was working. Kela is a student and Lomba’s neighbor in Poverty Street.Kela learned the postcolonial history in Nigeria through his English teacher who is an activist and through his other encounters. Alice is Lomba’s first love. However, their love story did not have a happy ending because Alice obligatory married a rich man so that she can pay the hospital bills of her mother. Joshua Amusu was a teacher and an activist who asked Lomba to cover his demonstration against a fraudulent government. The Plot Helon Habila portrays the novel â€Å"Waiting for an Angel† taking place during the regime of General Sani Abacha, when turmoil and violence is on the rise.The story introduced Lomba as an idealistic student in Lagos who attempts to write novels in his apartment in Morgan Street while working for the newspaper, the Dial. Shortly, his roommate Bola was attacked and beaten by police officers during that time along with other journalists. Meanwhile, offices of Dial were also burnt. After the entire incidence, Lomba chooses to participate in prodemocracy protest. During the demonstration, he was seized and put into jail for three years. This novel was narrated in a flashback.It started with Lomba’s situation in jail and finished with highlight events going to his detention (Zaleski) References: Jeff Zaleski. â€Å"Waiting for an Angel. † Rev. of: title_of_work_reviewed_in_italics, clarifying_information. Publishers Weekly 9 Dec. 2002: 61. ABI/INFORM Global. ProQuest. ***INSERT Library name or system, City, State ***. 14 Aug. 2007 http://www. proquest. com/ Bures, Frank. Everything Follows: An Interview with Helon Habila. 14 August 2007 . Whipple, Mary. Waiting for an Angel. 01 June 2004. 14 August 2007 .

Integrated Circuit Design

Integrated circuit design, or IC design, is a subset of electrical engineering and computer engineering, encompassing the particular logic and circuit design techniques required to design integrated circuits, or ICs. ICs consist of miniaturized electronic components built into an electrical network on a monolithic semiconductor substrate by photolithography. IC design can be divided into the broad categories of digital and analog IC design. Digital IC design is to produce components such as microprocessors, FPGAs, memories (RAM, ROM, and flash) and digital ASICs. Digital design focuses on logical correctness, maximizing circuit density, and placing circuits so that clock and timing signals are routed efficiently. Analog IC design also has specializations in power IC design and RF IC design. Analog IC design is used in the design of op-amps, linear regulators, phase locked loops, oscillators and active filters. Analog design is more concerned with the physics of the semiconductor devices such as gain, matching, power dissipation, and resistance. Fidelity of analog signal amplification and filtering is usually critical and as a result, analog ICs use larger area active devices than digital designs and are usually less dense in circuitry. Modern ICs are enormously complicated. A large chip, as of 2009 has close to 1 billion transistors. The rules for what can and cannot be manufactured are also extremely complex. An IC process as of 2006 may well have more than 600 rules. Furthermore, since the manufacturing process itself is not completely predictable, designers must account for its statistical nature. The complexity of modern IC design, as well as market pressure to produce designs rapidly, has led to the extensive use of automated design tools in the IC design process. In short, the design of an IC using EDA software is the design, test, and verification of the instructions that the IC is to carry out FundamentalsIntegrated circuit design involves the creation of electronic components, such as transistors, resistors, capacitors and the metallic interconnect of these components onto a piece of semiconductor, typically silicon. A method to isolate the individual components formed in the substrate is necessary since the substrate silicon is conductive and often forms an active region of the individual components. The two common methods are p-n junction isolation and dielectric isolation. Attention must be given to power dissipation of transistors and interconnect resistances and current density of the interconnect, contacts and vias since ICs contain very tiny devices compared to discrete components, where such concerns are less of an issue. Electromigration in metallic interconnect and ESD damage to the tiny components are also of concern. Finally, the physical layout of certain circuit subblocks is typically critical, in order to achieve the desired speed of operation, to segregate noisy portions of an IC from quiet portions, to balance the effects of heat generation across the IC, or to facilitate the placement of connections to circuitry outside the IC. Design stepsA typical IC design cycle involves several steps: 1. Feasibility study and die size estimate 2. Functional verification 3. Circuit/RTL design 4. Circuit/RTL simulation Logic simulation 5. Floorplanning 6. Design review 7. Layout 8. Layout verification 9. Static timing analysis 10. Layout review 11. Design For Test and Automatic test pattern generation 12. Design for manufacturability (IC) 13. Mask data preparation 14. Wafer fabrication 15. Die test 16. Packaging 17. Post silicon validation 18. Device characterization 19. Tweak (if necessary) 20. Datasheet generation Portable Document Format 21. Ramp up 22. Production 23. Yield Analysis / Warranty Analysis Reliability (semiconductor) 24. Failure analysis on any returns 25. Plan for next generation chip using production information if possible Digital designRoughly speaking, digital IC design can be divided into three parts ESL design: This step creates the user functional specification. The user may use a variety of languages and tools to create this description. Examples include a C/C++ model, SystemC, SystemVerilog Transaction Level Models, Simulink and MATLAB. RTL design: This step converts the user specification (what the user wants the chip to do) into a register transfer level (RTL) description. The RTL describes the exact behavior of the digital circuits on the chip, as well as the interconnections to inputs and outputs. Physical design: This step takes the RTL, and a library of available logic gates, and creates a chip design. This involves figuring out which gates to use, defining places for them, and wiring them together. Note that the second step, RTL design, is responsible for the chip doing the right thing. The third step, physical design, does not affect the functionality at all (if done correctly) but determines how fast the chip operates and how much it costs. RTL designThis is the hardest part, and the domain of functional verification. The spec may have some terse description, such as encodes in the MP3 format or implements IEEE floating-point arithmetic. Each of these innocent looking statements expands to hundreds of pages of text, and thousands of lines of computer code. It is extremely difficult to verify that the RTL will do the right thing in all the possible cases that the user may throw at it. Many techniques are used, none of them perfect but all of them useful – extensive logic simulation, formal methods, hardware emulation, lint-like code checking, and so on. A tiny error here can make the whole chip useless, or worse. The famous Pentium FDIV bug caused the results of a division to be wrong by at most 61 parts per million, in cases that occurred very infrequently. No one even noticed it until the chip had been in production for months. Yet Intel was forced to offer to replace, for free, every chip sold until they could fix the bug, at a cost of $475 million (US). Physical design It has been suggested that this article or section be merged with Physical design (electronics). (Discuss) Here are the main steps of physical design. In practice there is not a straightforward progression – considerable iteration is required to ensure all objectives are met simultaneously. This is a difficult problem in its own right, called design closure. Floorplanning: The RTL of the chip is assigned to gross regions of the chip, input/output (I/O) pins are assigned and large objects (arrays, cores, etc. ) are placed. Logic synthesis: The RTL is mapped into a gate-level netlist in the target technology of the chip. Placement: The gates in the netlist are assigned to nonoverlapping locations on the die area. Logic/placement refinement: Iterative logical and placement transformations to close performance and power constraints. Clock insertion: Clock signal wiring is (commonly, clock trees) introduced into the design. Routing: The wires that connect the gates in the netlist are added. Postwiring optimization: Performance (timing closure), noise (signal integrity), and yield (Design for manufacturability) violations are removed. Design for manufacturability: The design is modified, where possible, to make it as easy and efficient as possible to produce. This is achieved by adding extra vias or adding dummy metal/diffusion/poly layers wherever possible while complying to the design rules set by the foundry. Final checking: Since errors are expensive, time consuming and hard to spot, extensive error checking is the rule, making sure the mapping to logic was done correctly, and checking that the manufacturing rules were followed faithfully. Tapeout and mask generation: the design data is turned into photomasks in mask data preparation. Process cornersProcess corners provide digital designers the ability to simulate the circuit while accounting for variations in the technology process. Analog designBefore the advent of the microprocessor and software based design tools, analog ICs were designed using hand calculations. These ICs were basic circuits, op-amps are one example, usually involving no more than ten transistors and few connections. An iterative trial-and-error process and â€Å"overengineering† of device size was often necessary to achieve a manufacturable IC. Reuse of proven designs allowed progressively more complicated ICs to be built upon prior knowledge. When inexpensive computer processing became available in the 1970s, computer programs were written to simulate circuit designs with greater accuracy than practical by hand calculation. The first circuit simulator for analog ICs was called SPICE (Simulation Program with Integrated Circuits Emphasis). Computerized circuit simulation tools enable greater IC design complexity than hand calculations can achieve, making the design of analog ASICs practical. The computerized circuit simulators also enable mistakes to be found early in the design cycle before a physical device is fabricated. Additionally, a computerized circuit simulator can implement more sophisticated device models and circuit analysis too tedious for hand calculations, permitting Monte Carlo analysis and process sensitivity analysis to be practical. The effects of parameters such as temperature variation, doping concentration variation and statistical process variations can be simulated easily to determine if an IC design is manufacturable. Overall, computerized circuit simulation enables a higher degree of confidence that the circuit will work as expected upon manufacture. Coping with variabilityA challenge most critical to analog IC design involves the variability of the individual devices built on the semiconductor chip. Unlike board-level circuit design which permits the designer to select devices that have each been tested and binned according to value, the device values on an IC can vary widely which are uncontrollable by the designer. For example, some IC resistors can vary  ±20% and ? of an integrated BJT can vary from 20 to 100. To add to the design challenge, device properties often vary between each processed semiconductor wafer. Device properties can even vary significantly across each individual IC due to doping gradients. The underlying cause of this variability is that many semiconductor devices are highly sensitive to uncontrollable random variances in the process. Slight changes to the amount of diffusion time, uneven doping levels, etc. can have large effects on device properties. Some design techniques used to reduce the effects of the device variation are: Using the ratios of resistors, which do match closely, rather than absolute resistor value. Using devices with matched geometrical shapes so they have matched variations. Making devices large so that statistical variations becomes an insignificant fraction of the overall device property. Segmenting large devices, such as resistors, into parts and interweaving them to cancel variations. Using common centroid device layout to cancel variations in devices which must match closely (such as the transistor differential pair of an op amp). VendorsThe four largest companies[citation needed] selling electronic design automation tools are Synopsys, Cadence, Mentor Graphics, and Magma.

20 Computer Terms You Should Know

20 Computer Terms You Should Know 20 Computer Terms You Should Know 20 Computer Terms You Should Know By Simon Kewin A great deal of jargon is used when talking about computers, and it’s surprising how often these terms are used incorrectly. Even published, successful novels sometimes do so. The following list provides an explanation of some of the more common computing terms you may come across or need to employ in your own writing. Internet, World Wide Web The Internet is the network of computers we’re all familiar with. It’s quite common for the terms â€Å"Internet† and â€Å"World Wide Web† to be used interchangeably, but these aren’t actually the same thing. The Internet is essentially the wiring that allows computers all over the world to communicate. The World Wide Web is a system that operates via this wiring. Web pages are transmitted via Internet connections but there is more to the Internet than just the web. Many other types of data travel across the Internet too, for example email. Web Browser A program you use to look at, and navigate between, pages on the World Wide Web. Examples include Internet Explorer and Firefox although there are many others. Again, people sometimes refer to web browsers as â€Å"the Internet†, whereas they really only provide the means to view pages on the web. Bandwidth, Broadband Bandwidth is an indication of how quickly data travels along a connection. The greater the bandwidth, the faster data will be sent and received. Broadband is a rather vague term that refers to bandwidth somewhere above that of an old dial-up modem, although there is no precise definition of the term. Broadband connections are generally â€Å"always on†, unlike modem connections. There are various technologies which provide â€Å"broadband† speeds – such as ADSL, cable, satellite etc. Modem The word modem was originally coined in the days when computers communicated by converting numbers into sounds that could then be transmitted over a regular telephone line. At each end you needed a â€Å"modulator† to generate the sounds to transmit and a â€Å"demodulator† to convert received sounds back into numbers. From â€Å"MOdulator/DEModulator† came the word modem. With modern digital communication, no conversion to and from audible sounds is required, but even so it’s common to hear people talking about â€Å"broadband modems† or â€Å"ADSL modems† when referring to devices providing broadband connectivity. Strictly speaking, such devices are not modems at all as they communicate digitally but the word has stuck; its meaning has shifted to refer to digital devices as well. Memory, Disk Space Another very common source of confusion. In computing, â€Å"memory† generally refers to the temporary storage used by a computer whilst it is switched on. A computer loads programs and data into its memory in order to carry out tasks. This is more accurately called RAM or â€Å"random-access memory†. Disk space (or â€Å"hard disk space†), on the other hand, is a more permanent store that holds files even when the computer is switched off. It’s from here that the computer loads things into its memory. Strictly speaking you don’t store things in the computer’s memory as that vanishes when you turn the machine off. Virus, Spyware, Trojan, Worm, Malware These terms are often confused, although they have distinct meanings. A virus is a piece of software that can copy itself and which attaches itself to some other program in order to survive and replicate. It may have some malicious intent or it may exist simply to reproduce. A worm is similar but it can exist independently; it doesn’t need to attach to a separate program. A Trojan – or Trojan Horse – is a piece of software that gains access to a computer by pretending to be benign or by hiding within some innocent-looking application. The name is obviously derived from the wooden horse employed by the Greek army during the Trojan Wars. Spyware is software that secretly monitors computer activity, attempting to gain private information without the computer user knowing. By and large, all of the above will have some malicious intent – to harm data, spy on computer activity and so forth. Malware is a general term for all such programs – it simply means any software, of whatever sort, written with a malicious intent. Viruses are generally malware but there is more to malware than just viruses. Bits, Bytes At a basic level, all computer data is just a series of 0s and 1s. Each of these is referred to as a â€Å"binary digit†, for which â€Å"bit† is just an abbreviation. A byte is (generally) a collection of eight bits, so called because of the pun with bit and bite. Similarly a collection of four bits – half a byte – is sometimes called a â€Å"nybble†. In order to refer to large numbers of bits and bytes, various prefixes are used, as in : 1 kilobyte = 1024 (or 1000) bytes 1 megabayte = 1024 (or 1000) kilobytes 1 gigabyte = 1024 (or 1000) megabytes 1 terabyte = 1024 (or 1000) gigabytes 1 petabyte = 1024 (or 1000) terabytes Reboot To switch a computer off and on again, allowing its operating system and programs to be reloaded. Note that this is not the same as placing a computer into standby/hibernate and then resuming. A reboot requires that all software is completely reloaded. The term derives from â€Å"bootstrap†, as in the phrase â€Å"to pull oneself up by one’s bootstraps†, because of the similarity to that seemingly impossible act (as a computer can’t run without first loading some software but must be running before any software can be loaded). Cookie A small text file sent to your computer by a web site you have visited. These can be very useful in that they can allow the web site to recognize who you are when you return. Cookies cannot store viruses or other threats, although they can be used to track your activity across different web sites in order to provide, for example, â€Å"targeted† advertisements. Firewall A firewall is a piece of computer software or hardware that restricts the data that is allowed to flow through. Firewalls block traffic that is undesirable in some way, the intention being to prevent infection by malware and so on without restricting the user from carrying out legitimate activity. Spam Unsolicited email messages sent out in bulk and generally commercial in nature. In fact the term is used more widely these days to refer to such messages in a variety of places, not just on email – for example comments on blogs. The origin of this sense of the word spam is unclear. CAPTCHA CAPTCHA checks are the strings of letters and numbers that have to be typed in on some web pages before something can be saved. They exist because, although humans find interpreting these strings relatively easy, computers do not. Setting up these checks therefore blocks an automated process – such as one generating spam – from using the page, whereas a human is still able to. The acronym CAPTCHA actually stands for â€Å"Completely Automated Public Turing test to tell Computers and Humans Apart† – a rather contrived way of arriving at an acronym that sounds like the word â€Å"capture†. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Vocabulary category, check our popular posts, or choose a related post below:Arrive To vs. Arrive At50 Idioms About Meat and Dairy Products10 Types of Hyphenation Errors

15 Hilarious Pranks to Pull on College Friends

15 Hilarious Pranks to Pull on College Friends Oh Lord, there are so many hilarious pranks to pull on college friends. Listen, if you’re looking for prank ideas and don’t want to get sucked into hours of prank videos, this article is for you. Here are 15 that you can always count on, as long as they go off without a hitch and are executed safely. #1 Tape the Contents of Their Trash to Their Door Make a statement. You can find out a fair amount about a person by exposing their trash. Go into their room, especially if they’re super-messy and tape everything (within reason of course) that’s trash onto their door and let them know it’s time to clean up! #2 Fill Their Dorm Room with Popcorn This is a cheap and easy trick. Making it goes really quick and you can easily fill an entire dorm room with only about 8 or 9 bags which cost maybe $2 each. Transporting it is easy as well†¦.industrial-sized trash bags. The trick is that ideally you should be able to leave the room through the window so you can make the popcorn 5 feet tall (or more)! #3 Put a Dead Thing in Their Cereal No, not a real dead thing, but a realistic looking one. It’s not over-the-top but it works (especially on girls) you could either big a furry spider in there of substantial size, a small snake, or perhaps even a rate. #4 Change Their Computer Log-In Sounds This is truly legendary. If you can get their log in information, or get into the computer while they’re away change the log-in sound to something crazy. Anything from a full-on gun fight to a ground shaking explosion with screams of terror. Then, turn their sound system up super-loud (not so loud you blow speakers) so that the next time they expect to hear some pleasant sound suddenly they’re under siege and could potential crap themselves. #5 The Almighty Soda Bomb Mentos are pretty old. But, what you do is put a tiny hole through one, latch it onto a string and then drop it into a big bottle of soda and close the cap tightly. Simply put it back in the fridge and wait. The next person who opens that will be bombarded with fizz and syrup unlike anything they’ve ever experienced before. #6 Butter Tiles Again, cheap and easy but effective. If you have any tiles, butter them up and then wait because regardless of what kind cleats someone may be wearing they’re going to end up on their butt. Really good for roommates or college friends with hard wood floors. # 7 Completely Cover them in Flour While they Sleep Don’t pour it on so they wake up. No, instead grab like 10 bags of flour (that’s a pretty hefty clean up job remember) and slowly stealth fully cover your college buddy while they sleep. Flour is actually quite comfortable. #8 Early Alarm + Flattened Tires They’re the type of person that jet’s out of bed last minute, scrambles onto their bikes and heads off to class. Okay, so set the alarm an hour ahead of schedule (and any other clocks in the room along with it) and then flatten the tires so they think they’re going to be late. #9 Put a Fake Person In their Bed Get a realistic looking mannequin and sneak them into bed next to someone. Making the mannequin’s face scary is a bonus. They could wake up in the night screaming, or they could wake up in the morning to an unexpected stranger. Hilarious. #10 Opposite Side Switch This one doesn’t make a mess, it’s free and it’s funny. While they’re away at class sneak into their room and switch everything to the opposite side so it’s a perfect match. Then, when they bring it to your attention, seriously act as if they’re nuts and it’s been that way the whole time. If you can hold your composure it will play an epic mind prank on them. #11 Early Morning Shower Prank Simply sneak into the dorm shower while they’re getting ready for another day of collegiate labor and steal their towel and clothes so they will have no other option but to grab the shower curtain. However, this may not occur to them for some time. #12-   Shaving Cream Floor Cover the floor, completely, in fragrant shaving cream. Super cheap, and not as hard to clean up. #13 Wrapping Paper Room Grab some festive wrapping paper and thoroughly set about wrapping their entire room in it. Even if it takes 10 rolls, that’s probably only $20 to do a full single dorm room. #14 Pubic Hair + Superglue Seriously, if they have a problem cleaning up their pubes, then (with gloves on) grab a bunch of the stuff and super clue it to something that’s valuable enough to them that they’ll get the point. #15 Wake Up in Unexpected Places If they’re a heavy sleeper or utterly passed out, have them wake up in a strange place. This is so awesome when pulled off correctly. We had to boil it down to these because there are hundreds of pranks out there. But, with a little creativity you could come up with just about anything. Check out even more cruel but funny roommate pranks! How about it gang, what kinds of pranks have you played on college friends that they’ll never forget?

Meaning and Origin of the Surname Chavez

Meaning and Origin of the Surname Chavez Chaves is an ancient Portuguese surname that literally means keys, from the Portuguese Chaves  and Spanish laves (Latin  clavis). Often an occupational surname was given to someone who made keys for a living. Chavez is also an alternate spelling of the Chaves surname, which in Portugal was often a  habitational name from the town of Chaves, Tras-os-Montes, from the Latin acquis Flaviis, meaning [at the] waters of Flavius.   Chavez is the 22nd most common Hispanic surname. Surname Origin:  Spanish, Portuguese Alternate Surname Spellings:  CHAVEZ Famous People With the Surname Cesar Chavez: American civil rights leaderHugo Chavez: President of VenezuelaNicole Chavez: Hollywood celebrity stylist Where in the World Do People With the Surname Live? According to surname distribution data from  Forebears, Chaves is the 358th most common surname in the world- found most commonly in Mexico, with the highest density of the surname present in Peru. Chavez is also a common last name in Bolivia, where it ranks 18th most popular in the nation, as well as Ecuador, El Salvador, Guatemala, Philippines, Honduras, and Nicaragua.  WorldNames PublicProfiler  also has the surname as most common in Argentina, especially Northwest and Gran Chaco, as well as New Mexico in the United States, and southwest Spain (Andalucia and Extremadura provinces). Genealogy Resources for the Surname CHAVES Family DNA ProjectA Y-DNA project focused on family and genetic relationships between the various Chaves families around the world. This includes the Chavez and Caceres surnames of Spain. Chavez Family Crest - Its Not What You ThinkContrary to what you may hear, there is no such thing as a Chavez family crest or coat of arms for the Chavez surname.  Coats of arms are granted to individuals, not families, and may rightfully be used only by the uninterrupted male-line descendants of the person to whom the coat of arms was originally granted. Source: Cottle, Basil.  Penguin Dictionary of Surnames. Baltimore, MD: Penguin Books, 1967. Dorward, David.  Scottish Surnames. Collins Celtic (Pocket edition), 1998. Fucilla, Joseph.  Our Italian Surnames. Genealogical Publishing Company, 2003. Hanks, Patrick, and Flavia Hodges.  A Dictionary of Surnames. Oxford University Press, 1989. Hanks, Patrick.  Dictionary of American Family Names. Oxford University Press, 2003. Reaney, P.H.  A Dictionary of English Surnames. Oxford University Press, 1997. Smith, Elsdon C.  American Surnames. Genealogical Publishing Company, 1997.

Sprite (Marketing strategy, budgets, and controls) Essay

Sprite (Marketing strategy, budgets, and controls) - Essay Example In the recent past, government agencies and health professional have been awareness on some potential health problems such as obesity among the consumers. Being a food product, sprite faces many challenges, as obesity is now a big health issue (Turner, 2000). Commitment is important for the Sprite to ensure that its broad product include another option of beverage whose health value deal with the obesity and problem. This is possible by including an option that is lemon flavored, but does not include a lot of sugar. Sprite is committed to adhering to the set policies in schools and marketplace. They aim at meeting customer need through provision of product’s varieties such Sprite Zero and other varieties that meet every consumer needs. Furthermore, sprite in corporation with different government agencies, consumers, and schools to bring a solution based on underlying science. Water quality and quantity is also another challenge facing Sprite marketing strategies. Water quantity and quality are increasingly demanding a lot of attention and collaboration with other non-alcoholic beverages produces, governmental agencies, and communities. Water is a key Sprite’s ingredient among the beverages produce and due to climatic changes; it has become a scarce resource. In order to curb the problem, the company is partnering with communities and government organization in introducing initiative for water preservation, water treatment, and recycling (Turner, 2000). Globalization is also introducing new challenges to sprite products. Globalization is making human lifestyle and market places dynamic. The consumers’ needs is increasing becoming complex. For this reason, Sprite product is forced to concentrate in the evolving consumer’s product and consumers are looking for more and more ideal choices. There is now a number shift in

Artist Statement Essay Example | Topics and Well Written Essays - 500 words

Artist Statement - Essay Example Some of the information include the creature habitats and habits. Further, nocturnal photos can be used in studying the rare animals that only come out at night because during the day they hide in their caves. These animals are known as nocturne creatures. Additionally, nocturnal photos on animals can be stored in archives for future reference thus act as a source of information to researches and zoology students in educational centres. In addition, this practice of taking photos is essential in establishing the near extinction animals. Thus helps to trigger the need to protect them from extinction by establishing measures that will mitigate the rate of extinction. However, nocturnal photos promotes art because it gives artisans ideas on what to draw and even curve thus enhancing creativity. Additionally, from the curves and the drawing future generations can learn about the creatures. Moreover, this photos in a way help to market countries to tourists who are in love with animals and wish to explore more. Through this, a country will receive an increase in the number of tourists visiting their nation, hence uplifting it gross domestic product. Furthermore, the characteristics that accompany the nocturnal photos can be of great use to game wardens by educating them on how to handle those animals effectively to avoid damage or injuries since some of them are poisonous. Secondly, nocturnal photos about human beings are taken in special occasions conducted during the night. Events like film shooting, fire bourn parties and many more. Therefore, these photos can be stored and referred to in future to remember the Good times in a person’s life. Thirdly, nocturnal photos about unique structural features are used to highlight the features of a nation. By doing this it will attract tourism to their states. This structural nocturnal photos can also be places in school libraries to teach the students

LABELLING THEORY HAS NO IMPACT ON REAL WORLD DECISION MAKING PRACTISES Essay

LABELLING THEORY HAS NO IMPACT ON REAL WORLD DECISION MAKING PRACTISES - Essay Example Although labelling theory may have influences in different settings, it does not necessarily entail that all decisions be based upon it, as will be discussed in this paper. The theory Labelling theory presents that â€Å"deviance is a socially constructed process in which social control agencies designate certain people as deviants, and they, in turn, come to accept the label placed upon them and begin to act accordingly† (Kendall, 2007, pp. 188-189). There are several versions of the theory, of which the ideas of Howard Becker, seen to be a major proponent of the theory, will primarily be considered in the present paper. One famous statement by Becker upheld in this theory is, deviant as â€Å"one to whom the label has successfully been applied; deviant behavior is behavior that people so label† (as cited in Kendall, 2003, p. 189). Making labels Becker’s work in 1963, Outsiders: Studies in the Sociology of Deviance, is one of the most cited literature that focus es on labelling theory and deviance. According to him, only a few individuals have the power and qualifications to determine what is deviant or not, and they generally belong to the upper social classes (Franzese, 2009, p. 72). These individuals are called â€Å"moral entrepreneurs,† and are presented by Becker to be those who want to help the less fortunate, rather than being mean or evil (p. 72). The supposed intent of labelling was to take societal interests into consideration. However, because labeled individuals are inferior to those who have the capacity to label them in terms of power and status, the positive goal of labeling backfires to become what is usually seen to be negative and deviant to established norms. It is not emphasized how individuals can resist being labeled, but labeled individuals may be rehabilitated in the presence of interventions differing according to the deviant behavior. Consequences of labelling The labelling theory hypothesizes that deviance is not inherent, but rather a product of reaction to established societal norms, or results of societal perceptions. It presents a process where initially there is a pubic labelling which is informal at first but evolves to be formalized later; second, this label â€Å"overrides all the other symbols and statuses a person previously held,† and cause people to react very differently by rejecting or isolating the individual; and third, such label affects the individual’s self-perception and self-image, encouraging many to live according to that deviant label, or in other words accept that he or she is deviant and live according to it (Slattery, 2003, p. 135). This process outlines the consequences of labelling to the labeled individual, which are, most of the time, negative rather than positive. It is further contended that deviant behavior can be â€Å"cured† or rehabilitated, but doing so would not be easy, especially in the continuous presence of societal pres sure and rejection. Labelling in the real world In the context of the theory, labelling may be formal or informal, which is also a common criticism of the ideology. Informal labels are those that tend to be placed by family, friends, colleagues, acquaintances, et cetera. Formal labels are those given by health care, the police, the academe, and other institutions. Literature dealing with the theory often cite â€Å"mentally ill† as a common established label, as well as in aspects in criminology,

Do innovations really make us lazier Essay Example | Topics and Well Written Essays - 250 words

Do innovations really make us lazier - Essay Example Certainly, vehicles and other means of transport are inevitable in the current world; however, their discovery has greatly contributed to laziness. Humans are too much dependent on vehicles and bicycles, they go to sporting events, go to work, shopping and market through vehicles. Because of the changes, innovation has led to lifestyle diseases such as high blood pressure and obesity, hence a significant deterioration of the physical health (Anthony, 2012). In the education sector, students no longer get the full benefit and experience of expediting ignorance. Instead, computers, mobile phones and internet have replaced the role of students in learning. Computers have literally eliminated the ability of learners to spell words correctly and engage teachers in different subjects. Gradually, students are forgetting the role of hard work, but rely on the discretion of innovation to handle all problems. The on-going process seeks appliances that make hair, cook, wash, teach and facilitate security (Koschatzky, Kulicke & Zenker, 2001). Therefore, instead of technology making life easy and solving life challenges, it continues to make people

Integration paper Assignment Example | Topics and Well Written Essays - 1000 words - 1

Integration paper - Assignment Example Even though each of the concepts and theories learnt can be testified as transforming my learning in a very tremendous way, two concepts and theories I believe will continue to impact my corporate knowledge about emerging markets forever are the concepts on legal and ethical practices in emerging markets, and the ways in which local emerging businesses can effectively compete with multinational companies. These two concepts and theories are selected generally because they are transcending to both multinational companies and local companies. While learning about legal and ethical practice in emerging markets, I came to appreciate the kind of power and authority that the consumer in these emerging markets have as far as the command that they can have on the market is concerned. This is because for all this while, I thought that because most multinational companies that went to these emerging markets were from developed countries, they would go and influence the local people directly with their foreign ethics and culture. However, I have now come to appreciate the fact that culture and ethics are important concepts that establish the identities of people and so local consumers would not just allow the influx of foreign and strange ethics and legal practices to overtake what they have practiced for long. For multinational companies that are poised for success, the essential role that they can play is to admit a sense of readiness to comply by local ethical and legal standards. This is because with the ethical and legal inc lination that the local people have, they form a social hub, which is not easy to penetrate or break apart. Multinational companies must therefore see themselves as part of social network, where they are the ones who have to comply with set standards. The concept of competitions between local companies and multinational companies was

Construction planning Essay Example | Topics and Well Written Essays - 3500 words

Construction planning - Essay Example The SHE provisions or specifications outlined for the project seek to reduce or eliminate and mitigate incidents, injuries and environmental harm at the construction site. The project relies on expertise in environmental management, system design and innovation in evaluating and reducing the environmental impacts of all its phases; initiation, implementation, monitoring, evaluation and operationalisation. The envisaged solutions are suggested to increase the project’s market stability and guarantee sustainable benefits. The compliance of each stage of the project life cycle, starting with planning, will adhere to the set SHE standards. The on-site and off-site planning of project deliverables will have to be aligned with specific regulatory standards and requests. The standards cover dangerous substances traceability, recyclability of materials, supply-chain assessment, and obsolescence and substitution management. The planning must also consider environmental concerns and engage in long-term sustainable strategies, based on life cycle thinking (LCT). Through this approach, the planners will adopt a broader view of the project’s successful implementation, opportunities, viability and sustainability. The objectives set at the planning phase and the strategies and resources by which they will be achieved will also consider and address the SHE standards. The project will seek expert assistance in the implementation of the project and use astute management strategies to achieve sustainability, performance and reduce project risks. At the implementation phase, a checklist and design specification will be outlined and communication with all stakeholders managed properly. In addition, sustainable supply processes and implementation activities will be used. Equally important at this phase will be the integration of multisite and transnational

Integration paper Assignment Example | Topics and Well Written Essays - 1000 words - 1

Integration paper - Assignment Example Even though each of the concepts and theories learnt can be testified as transforming my learning in a very tremendous way, two concepts and theories I believe will continue to impact my corporate knowledge about emerging markets forever are the concepts on legal and ethical practices in emerging markets, and the ways in which local emerging businesses can effectively compete with multinational companies. These two concepts and theories are selected generally because they are transcending to both multinational companies and local companies. While learning about legal and ethical practice in emerging markets, I came to appreciate the kind of power and authority that the consumer in these emerging markets have as far as the command that they can have on the market is concerned. This is because for all this while, I thought that because most multinational companies that went to these emerging markets were from developed countries, they would go and influence the local people directly with their foreign ethics and culture. However, I have now come to appreciate the fact that culture and ethics are important concepts that establish the identities of people and so local consumers would not just allow the influx of foreign and strange ethics and legal practices to overtake what they have practiced for long. For multinational companies that are poised for success, the essential role that they can play is to admit a sense of readiness to comply by local ethical and legal standards. This is because with the ethical and legal inc lination that the local people have, they form a social hub, which is not easy to penetrate or break apart. Multinational companies must therefore see themselves as part of social network, where they are the ones who have to comply with set standards. The concept of competitions between local companies and multinational companies was

Toyota Recall Essay Example | Topics and Well Written Essays - 500 words

Toyota Recall - Essay Example In the late 1990’s Toyota’s operating profits were as high a 2 trillion yen in China. However, Toyota turned its back on the deficit owing to the financial crisis. The reason for the recall is mainly attributed to the management which was not able to keep up with the increase in sales that in turn affected the quality; while at the same time the scale of the company continued to grow. Before the recall happened a warning was issued to the executives that stated â€Å"If we keep this up, Toyota would be faced with a recall.† The company extended beyond its capacity which worried the executives. And as some factories were built overseas, a large number of the workforce were shifted to the foreign countries. Hence the company had to make several adjustments which led to the decline of quality control (Wook 2010). A possible way by which the company can re-gain the trust of motor vehicle consumers is by investing in commercials that project a good image of the company. It could also consider incorporating other aspects such as quality in the campaign. Cost-effectiveness of Toyota products will be a good step to start with in addition to insistence on durability. The recall is only a beginning and a positive step but however, it does not provide a complete solution to the problem as the technical problem of the pedal is not the main issue. The Toyota Company should be prepared to go the extra mile in order to reassure consumers that it has resumed its core value which is based on quality. It is likely that the problem lies in the lack of coordination between the branches which in turn compromises all its efforts in effective decision making. If it is able to correct these problems the company can hope that the public will forget the unfortunate incidences soon and help it grow. The recall has however had a positive influence on the Toyota brand

Australia Has Regional and Global Links Essay Example for Free

Australia Has Regional and Global Links Essay Australia has regional and global links with other countries for aid. This report will describe the advantages and disadvantages for Australia that result from its Indonesian aid links which includes improving Australia’s reputation and providing employment and training opportunities for people. However country may become too dependent on other countries for support and dishonest leaders may use the money for their own benefits. First and foremost, Australia is popularly known to be ‘champions of the underdog’ who believe in the ‘fair go’ principle. To not have an overseas aid program is thought to be inhumane and even unpatriotic. The Australian Overseas Aid Program argues that most Australians support Indonesian aid simply because they sincerely care about those who are less well off. Aid to Indonesia may then encourage a friendly relationship between them and Australia and the future of positive exchanges of cultural values. Secondly, by providing aid for countries such as Indonesia, it provides employment and training opportunities for Australians. Thousands of full and part-time jobs have been created in government and non-government aid agencies as well as in private firms. Voluntary aid has been said to benefit young people seeking work experience and retirees and unemployed people seeking worthwhile work. The theory is that voluntary work gives them valuable knowledge and work skills and improves cultural links between the two countries. However, when there are positives, there are always negatives. The disadvantage for Australia giving aid is that the receiving country of the aid can become too dependent on receiving that money. Instead of the country using the aid and becoming more independent by implementing programs and policies in their country, they remain dependent on the aid. For example, Australia gives Indonesia approximately 2 billion dollars a year. This is a concern because without Australian aid the people of Indonesia would be very poor. Furthermore, another disadvantage would include dishonest leaders abusing the money. Australian and international aid each year amounts to millions of dollars and unfortunately, must money is used by corrupt leaders who use the funds for their own benefits or to support their private armies. As a result, the aid does not get to the people who need it most. In summation, providing aid to other countries will always have its advantages and disadvantages. As seen from above, Australia benefited from providing aid to countries such as Indonesia because it provided employment and job opportunities for Australians and improved Australia’s reputation. However, providing too much assistant could result in the country becoming too independent or the money could be abused and used for the wrong purposes consequently, those who need it most don’t get the benefits.

Social Media Texting: Bad Grammar

Social Media Texting: Bad Grammar LOL and OMG have been the acronyms of the decade and have become a trend in the way people communicate. Social media has expanded so much that people are becoming dependent on the Internet and are creating their own language. Social media is making the younger generation develop bad grammar. This issue is a problem because it is making society incapable of structuring coherent sentences making this generation dumb. The time being spend on social media outlets cuts down on the time focusing on their education and grammar. Although some argue that social media helps people communicate better in their daily lives, social media and texting are placing a burden on education. Social media has triggered one from learning academic and professional communication skill, promoting bad grammar, and the lack of creativity. Social media is promoting bad grammar because people accustomed to writing colloquially when they write structured essays. Bad grammar has gotten so severe that people have made several appearances on news channels about social media and bad grammar. A video that was posted on Channel 19 KYTX which is a local news station in Tyler, Texas. It talks about how students are trying to use bad grammar in their essays, which they also use on Facebook and Twitter. Living in a social media world in which people try to communicate as fast as possible people keep conversations short. Kaylee McPherson says to KYTX, I dont even put periods, question marks or anything. I just type it and go (Austin).With the generation being based on technology people ending up not just texting in acronyms but also speaking them was bound to happen. McPherson states that, Now, they actually start talking it. I hear people talking and Im like you kind of sound dumb. Not only are teenagers using shorthand on social media but also in the classroom. Melanie McNeils a high school English teacher says that when she grades papers she sees t he lingo in their essays. Melanie McPherson says, Ok, this is one I see a lot. B4=before, OMG=oh my god, u=you, y=why (Austin). Instead of McNeil giving her students no credit for that type of language used in their essays, she talks to her students about the difference between casual language and academic language and when it is the appropriate time to use the two (Austin). This web lingo has increased so much that even the Oxford English dictionary has added the words: Lol, Omg,Tweet, Retweet and even Sext. There is justification that the world is changing due to social media. Ontario Waterloo University in Canada requires students to pass an English language skills test in order to be accepted into the university. According to the statistics 1/3 are failing and students are blaming social media. Ontario Waterloo is a great educational example of how we can resolve the grammar problem. People should be happy that Universities are taking such an effect on this problem then maybe at least the younger generation will try harder to fix their grammar and spend less on social media cites. Bad grammar and social media go hand in hand people. People are so excited to send an instant message that they use shorthand of words and do not use full sentences. This is a server problem that needs to be addressed and people need to communicate effectively to change the bad grammar that our generation has developed. Being depended on social media affects people because they stop communicating and it will eventually affect them in long run. Switching from academic to colloquial language is difficult for most getting accustomed to changing the language and it is declining grammar skill. In the article, No LOL matter: Tween texting may lead to poor grammar skills by Pen State Official University News Source this article discuss how tweens who are in the age range between nine and fourteen are texting in acronyms and according to researches are decline language and grammar skills(par. 1). Text messaging may be an easy and fast way for one to communicate but according to Drew Cingel who is a Distinguished Professor of Communications and co-director of the Pen States Media Effects Research Laboratory states that, The use of these shortcuts may hinder a tweens ability to switch between techspeack and normal rules of grammar(par. 5). Teachspeak is when someone uses shortcuts while texting, on a social media site or chatting, such as U for You. Cingel gave middle school children in Pennsylvania a grammar assessment test at a 9 th grade level to see if everyone up to par she eventually stated after receiving the scores, Overall, there is evidence of a decline in grammar scores based on the number of adaptions in sent text messages(par. 8). The most people text the more they will adapt to that type of style and will not be about to distinguish whether they are writing proper or not. In High School I always experienced teachspeak, when I was in my English class the teacher would tell us to peer review each others essay. I would always notice that in every paper I would peer review I would at least see one or more tachspeak errors where someone would u instead of you .That is why researches have stated that it is affecting childrens grammar. Some may say that social media has been a way to connect with our lost love ones and some researchers have stated that social media is the downfall of the generation. The Internet is growing rapidly and it and has created many alternative ways from one to get information such as Dictionary.com, where one can look up a definition instead of grabbing a dictionary and instead of reading a book there are books online that you can use on your Ipad or kindle. Social media and texting has have a downfall on our grammar and it is getting harder to multitask. In the article, Yes, People Still Read, But Now Its Social by Steven Johnson it explains how people are reading books on a Kindle but Mr.Carrs who is the author of, The Shallows states, These distraction comes with heavy cost scientific studies show how multitasking harms our concentration(427). Due to social media such as Twitter, Facebook,and YouTube etc. being used all at once people are less likely to be able to focus. People who mul titask more are going to be faced with certain challenges in school when they are not able to concentrate in their studies. According to a study they found out that, Heavy multitasking performed about about 10 to 20 percent worse on most test than light multitasking (427). So it is true that Social media is making us dumb, people may read books on Kindle and might be happy that they are reading books but Mr.Carrs concern is that people are not thinking with a high-level mind set and people are reading pages on a screen. I feel like if society is going to depend on the internet eventually people will stop talking in complete and full sentences and will start using acronyms and that will affect peoples grammar when they are trying to write in an educational matter. The statistics for text messages have increased over the years. According to the Chicago Tribute that stated that Pew Research claims, 72% of adults and 87% of teens send and receive text messages(par.2). It is not only the teenagers that are constantly texting but also adults who are texting away. An executive editor of the American Heritage Dictionary named Steve Kleindetr says that when you text you may want to pay close attention to your attention. Kleinder gives us an example, If youre texting a friend who has difficulty with loose grammatical standards, be sure to spell out u (par. 2). This is a great point that Kleinder stated one must always think about the audience if it is either sending a text message or an email. No one will send an email to their boss saying Sup, cant make 2 wrk L8ts and especially if you had a friend who struggles with grammar you would write out everything clearly. Grammar is a huge part of our society and, People will always judge you, so write with that in mind, Kleinedler says. I personally have never wrote in short hand reason being that I struggle in English and I am not a very good speller, and if I were to write colloquialisms I would not help myself. That is why I made a pact with myself to always write in complete sentences if I am either texting on Facebook or Twitter no matter what. This has actually been beneficial to me because I have never written colloquiums in my essays I might still be a bad speller but at least I do not do it on purpose. Our generation will never be the same the Internet will always have some sort of power over us and with the development of technology increasing there is nothing we can do but educate ourselves. Just because everyone is texting and on Facebook sounding illiterate does not mean we have to do it too. We must take a stand and show society that the generation might be powered with technology but we are using it for our education and other beneficial things. Grammar will always be a problem and it can be fixed but with so many Social media outlets using Weblingo there is no way everyone will stop trying to be cool and rebel against it. Some people will not want to do it but they are dumb-ing themselves down. People need to learn how to talk proper and how to communicate instead of through Facebook and over a text. If this issue is not fixed our generation will be destroyed and there will be no way to fix it. Septic Shock Case Study: Causes and Effects Septic Shock Case Study: Causes and Effects Introduction Septic Shock is a serious circulatory disorder often characterised by a whole- body inflammatory state and the systemic response to infection (Titheradge, 1998), with the most common cause being the contamination of blood with bacteria. Septic shock is defined as sepsis with hypotension which develops in almost half of all septic patients as a complication with a mortality rate of 40-60% (Titheradge, 1998). Septic shock often results in a progressive failure of the circulation to provide blood and oxygen to vital organs of the body resulting in impaired tissue perfusion and oxygen extraction (Thiemermann, 1997). The key symptoms include a severe fall in blood pressure (hypotension) with hypo-reactivity to vasoconstrictor agents (vasoplegia) which may lead to the dysfunction or failure of major organs including lungs, liver, kidneys and brain (multiple organ dysfunction, MODS) and ultimately death (Goligorski et al., 1997). Presently it is widely assumed that septic shock rarely shows similar symptoms in affected individuals and therefore it is difficult to detect and then consequently treat it (Groeneveld and Thijs, 1986). It is, however, also agreed that most of the therapeutic interventions invariably focus on the primary aim of fighting the refractory hypotension by the use of aggressive fluid infusions, glucocorticoids, large doses of vasoconstrictors (Baumgartner and Calandra, 1999) and occasionally renal replacement therapy (Wheeler Bernard, 1999). Yet these interventions do not offer consistent success (Parratt, 1997). In recent times, our understanding of the pathophysiology of septic shock has developed significantly through experimental and clinical trials, though the discovery of a suitable treatment with therapeutic efficacy is proving elusive (Baumgartner and Calandra, 1999). This is probably because of the heterogeneity of the clinical situations and the differences in host response to i dentical pathogens. Moreover evidence suggests that different pathogens which cause septic shock respond differently to the conventional treatments. Still, no effort has been made to treat patients according to the nature of the infecting organism (Gao, Anonymous, 1992). During the early 1990s nitric oxide (NO) emerged as a potentially substantial step towards the treatment of septic shock. This finding directed scientists to carry out numerous clinical trials and animal experiments with the objective of finding out more about the interrelation of NO and Sepsis (Cobb, 1999; Kilbourn, 1999). Later, the discovery of nitric oxide synthase (NOS) made this enzyme the primary target of therapeutic agents (Rosselet et al., 1998). However, recently a substantial amount of literature has been published with evidence contradicting the discoveries of earlier studies. Today more than a decade has elapsed without any resolution to the matter and even in this 21st century Septic Shock is invading the developing countries rapidly (Cobb, 1999; Kilbourn, 1999). This problem of a lack of significant advances in this field can be highlighted by the fact that 17 years have passed since the final publication of the Consensus Conference on sepsis and sepsis related syndromes (Rangel-Frausto, 2005). This paper conclusively defined sepsis and its symptoms with the hope of finding a suitable treatment in order to eradicate the disease (Rangel-Frausto, 2005). Today, however, the situation has not changed significantly with up to 750,000 new sepsis cases every year and 215,000 annual deaths in the United States (Trzeciak et al., 2008, Mitchell M. Levy, 2007). Additionally, in the population that survives such attacks, there is considerable morbidity with many scoring low in health related quality of life assessments (Kaarlola et al., 2003, Perl et al., 1995). Hence the 5 million lives campaign instigated by the US Institute of Healthcare Improvements, aims to minimize the prevalence of nosocomial sepsis (sepsis originating in a hospital) (Gao et al., 2008). This campaign aimed specifically at increasing safety and transforming the quality of hospital care (McCannon et al., 2007). Moreover, the Surviving Sepsis Campaign aims to improve the quality of life of septic patients using the best evidence available currently (Dellinger et al., 2004). Though the world mortality rates have declined in recent times, sepsis is gradually becoming more prevalent in the elderly in the developing countries (Gao et al., 2008).This is mainly due to the extended longevity of patients with chronic illnesses, the increased occurrence of immunosuppression, and the more frequent use of invasive procedures (Bone, 1991; Parrillo, 1993). Sepsis, severe sepsis, septic shock and multiple organ failure still dominate the mass cases of non coronary intensive care units (ICUs). This essay will attempt to explore the fundamental mechanisms leading to tissue and organ damage in septic shock through the investigation of a case study. Following this, the discovery and general biology of nitric oxide (NO) shall be discussed, and the experimental evidence implicating NO as an effector in sepsis, will be examined in detail. The results obtained from various pharmacologic interventions directed at NO in animal studies will also be considered. This report will also give an account of conventional and innovative treatments for the management of septic shock. Finally, data from the few available relevant clinical trials will be reviewed and possible future avenues of interest will be discussed. Systemic Inflammatory response syndrome and Septic Shock (Clinical Manifestation) Sepsis, severe sepsis and septic shock were inaccurately defined until a recently reviewed consensus conference in 1992 (Bone et al., 1992, Dellinger et al., 2004). In this meeting the term systemic inflammatory response syndrome (SIRS) was invented insinuating a clinical response arising from a nonspecific tissue damaging event (insult) (Rangel-Frausto, 2005). Sepsis as mentioned earlier is the result of substantial release of inflammatory mediators in response to an infection. However, often the same mediators are released in the absence of a documented infected in several medical conditions such as cardiopulmonary bypass (Wan S. et al., 1997), pancreatitis and trauma (Shanley TP. et al., 2006). Due to this, the early definitions of sepsis or septic shock were found to be misleading hence a North American consensus conference proposed a new terminology. In this conference sepsis was defined as a condition in which critically ill patients meet criteria for SIRS, in the context of infection. SIRS was defined as two or more of the following: 1) heart rate >90/min; 2) temperature >38Â °C or 12,000 or 20/min or a PCO2 3.5 L min-1 M-23; 2) hyperglycaemia (plasma glucose >120 mg/dL) in the absence of diabetes; 3) significant oedema or positive fluid balance (20 mL/kg over 20 h); 4) inflammatory variables: plasma C-reactive protein >2 SD above t he normal value or plasma procalcitonin >2 SD above the normal value and 5) mixed venous oxygen saturation (SVO2) >70% . (Dellinger RP et al., 2004). SIRS is generally not considered as a disease and its recognition does not provide any clinical conclusion. However, since it has proven to be a very useful for the identification of sepsis and its sequelae namely severe sepsis and septic shock it is regarded as a very important tool (Shanley TP. et al., 2006). Case Study: A 3-year-old boy was admitted to the intensive care unit because of fever, hypotension, and lethargy. A purpuric rash was noted on his arms and legs. Arterial blood gas analysis demonstrated hypoxemia and metabolic acidosis. The arterial lactate level was 10 mmol/L. He was intubated, resuscitated with crystalloid solution, started on broad-spectrum antibiotic therapy, and given dopamine to maintain a MAP above 55 mmHg. His chest radiograph revealed bilateral interstitial-alveolar infiltrates with a left sided predominance. Gram stain of the cerebrospinal fluid showed gram-negative cocci. The dopamine infusion was increased to 18Â µg kg-1min-1 for persistent hypotension and oliguria. Pulmonary and radial arterial catheter data yielded the following blood pressure, 85/30 mm Hg; MAP, 48 mm Hg; heart rate, 140 beats per minute; CVP, 10 mm Hg; pulmonary artery pressure, 22/14 mm Hg; PCWP, 12 mm Hg; cardiac index, 2.5L min-1m-2; and SVRI, 1226 dyne-sec-cm-5m-2. The boy was treated with ad ditional saline and an epinephrine infusion, which increased the MAP, cardiac index, and urine output. Arterial lactate levels decreased over the next 12 hours. Subsequent cultures of blood and cerebrospinal fluid grew Neisseria meningitidis. In this case the patient with acute organ failure and hypotension was diagnosed with septic shock. The young boy with meningococcal septic shock had a borderline-low cardiac index. Due to this a decrease in the cardiac index in this patient by the administration of an NOS inhibitor might not be desirable. This is suggestive of the fact that NO or its synthesising means cannot always be targeted in order to battle septic shock. I will attempt to go into further details with regards to this statement as we go along the essay. Nitric Oxide discovery: Joseph Priestly first identified gaseous NO in 1772. NO also named Nitrogen Monoxide is a very simple and tiny molecule consisting of one nitrogen and one oxygen molecule. Unknown of its fundamental physiological roles in the mammals, until the 1980s NO was widely considered as a mere toxic atmospheric pollutant (Konstantin J. Ovodov et al., 2000). In the 1980s researchers were examining how blood vessels expand (dilate) hence regulate the mean arterial blood pressure. Dilation of blood vessels, also termed vasodilation is a very important physiological response which partly regulates the blood pressure. By increasing the diameter of blood vessels, vasodilation causes the blood to travel more freely due to lower resistance (RF Furchgott, 1980). Since the blood vessel lumen widens during vasodilation, the blood imposes less outward pressure on the vessel wall hence reducing the blood pressure. In opposition, vasoconstriction reduces the diameter of the lumen increasing the BP. These physiological responses occur all the time in the human body regulating the BP and therefore are one of the most fundamental mechanisms of the human body. Dr Robert Furchgott and his group, later in 1980s investigated the role of acetylcholine in the smooth muscle relaxation and found that relaxation only occurred if a special class of cells called endothelial cells were present (RF Furchgott, 1980). These cells line the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall. Behind the endothelial cells are the smooth muscle cells which either relax or contract thus regulating the vascular tone (RF Furchgott, 1991). The same research group also discovered that smooth muscle were only able to vasodilate the blood vessels in the presence of endothelial cells. This indicated that there was some kind of factor that was being released by the endothelial cells which was involved in the dilation of the blood vessel. This factor was named Endothelium Derived Relaxing Factor (EDRF) and subsequently specified as NO (S Moncada et al., 1997). In 1977, Ferid Murad independantly investigated the mechanism of action of nitroglycerin and found that it worked by inducing the release of NO which in turn was able to cause relaxation of smooth muscle cells (F Murad et al., 1977). Louis Ignarro in 1986 finally resolved the whole perplex of EDRF and NO by declaring that EDRF was in fact NO. It was stated that both molecules showed identical properties when he compared gas Nitric Oxide and EDRF (Ignarro, L. J. Et al. 1987). In 1998, Nobel Prize in Physiology and Medicine was awarded to Drs. Robert Furchgott, Louis Ignarro, and Ferid Murad for their discoveries that vascular endothelial cells make nitric oxide (NO) and that such endothelium-derived NO stimulates cyclic guanosine monophosphate (cGMP) synthesis in the underlying vascular smooth muscle, causing relaxation (Kilbourn, 1999). Since the discovery of NO, vast number of its physiological roles in normal conditions have been reported including in the immune system, nervous system, reproductive system and other cellular functions. It has also been found to play important roles in variety of species ranging from mammals, to insects and plants. Role of Nitric Oxide in Biology Since it was first discovered to play a role in the dilation of blood vessels many new roles for Nitric Oxide (NO) have been discovered. In human body, NO is metabolised by its diffusion into red blood cells where it oxidizes the ferrous iron of oxyhemoglobin yielding methemoglobin and nitrate ions (NO3-) (J.M. Hevel et al., 1994 and Konstantin J. Ovodov and Ronald G. Pearl, 2000). This meachanism limits local NO build up and is particularly important in keeping NO concentration in naomolar range, at least in nonhydrophobic compartments (i.e. outside cell membranes) (Beckman Koppenol, 1996). Nitric oxide has been found to be produced by effectively every cell type in vivo and plays an important role in both controlling the normal function of cells as well as in regulating larger scale processes such as the reproductive, immune and nervous systems. A few of these biological functions for NO are described in more detail below. The Immune System Nitric oxide plays many important roles in the immune system although it is expressed in many cell types following endotoxin or pro-inflammatory cytokine treatment (C. Nathan et al., 1991 and R.G. Knowles et al., 1994). NO, in immune system, is produced in high amounts from specific cells called macrophages. Proceedingly to an infection, chemicals known as cytokines are release in vivo which activate the cells of the immune system such as macrophages, and help guide them to the site of infection (S. Moncada et al., 1991 and C. Nathan et al., 1991). NO produced by the macrophages is toxic to the bacteria and play an important role in their destruction (Fig 1). The production of nitric oxide in this way also helps protect against other types of infection including parasites and viruses (S. Moncada et al., 1991). However, too much nitric oxide production can not only lead to septic shock but has also been implicated in conditions where the immune system is too active autoimmune diseases like arthritis (Jang D and Murrell G A, 1998). The Nervous System Nitric oxide has been shown to be involved in both the peripheral and central nervous system. The three nitric oxide producing isotypes of enzyme (iNOS, eNOS, nNOS) (see section) in humans, one isotype (neuronal NOS (nNOS)) is found almost exclusively in the nervous system (Forstermann et al., 1995). nNOS is thought to be involved in promoting the transfer of interneuronal nerve signals. This is thought to take place by the stimulation of exocytosis (release) of endogenous chemicals called neurotransmitters of one neurone (Moncada et al., 1991; Forstermann and Kleinert, 1995). These NT then diffuse across the synaptic cleft (gap between neuronal terminals) and stimulate the neighbouring nerve cell terminal to transmit the signal (Otto Loewi, 1961). NO has shown to play a substantial role in diseases of the nervous system like Alzheimers and Parkinsons. In both diseases, the inhibition of NO has shown to slow down the progression of the disease in mice (Weill Cornell Team, 2005 and Jo hns Hopkins et al., 2004). Reproductive Biology Nitric oxide is one of the most important molecule in the course of reproduction and is involved in many aspects of it. As well as dilating the blood vessels and thereby helping to regulate maternal blood pressure, NO is also involved in implanting the early embryo in the uterus (Rogers, 1995). During pregnancy, nitric oxide is also suggested promote angiogenesis (a process in which new blood vessels are formed) (RayChaudhury et al., 1996). It is also known to play a role in the survival of trophoblasts (form placenta) (Enders et al., 1978). Furthermore deficiency of NO has been found in patients with preeclampsia (a medical condition in pregnancy) suggesting its partial role in growth of embryo (Yallampalli et al., 1994; Liao et al., 1996). In addition, drugs (Viagra) used to treat erectile dysfunction also affect nitric oxide signalling. Cellular function A notable number of cellular activities can be controlled by nitric oxide including cell division, cell movement and cell survival. The majority of cells in human body have the ability to undergo programmed cellular death. This is a self-destructive mechanism usually called apoptosis which often occurs when a cell is damaged and beyond repair, infected with a virus, or undergoing stressful conditions such as starvation (Kerr et al., 1972). Cells in these conditions go through apoptosis so that they dont hinder the proper functioning of the rest of the tissue. During apoptosis, the structures of the cell break down in an organised manner, forming a packaged cell that is smaller in size so that it can be easily removed by the cells of the immune system (Kerr et al., 1972). Nitric oxide was first shown to inhibit apoptosis hence promoting cell survival in human B lymphocytes (Mannick, J. B. Et al., 1994). Subsequently similar finding were reported in an ample number of other cells. However, high doses of nitric oxide also have deleterious effects. They can be toxic to many cell types and can lead to septic shock and multiple organ dysfunction syndrome (MODS) in which case NO causes cell death instead of promoting cell survival (Beal Cerra, 1994). Nitric Oxide and Inflammation (Pathophysiology of septic shock) This section will deal with mechanism by which wall fragments of Gram-negative or Gram-positive bacteria and other inflammatory agents induce nitric oxide synthase (iNOS) in cells and tissues. Exogenous toxins which enter the circulation stimulate the synthesis and release of a number of endogenous cytokines. During a gram-negative infection which can lead to septic shock, lipopolysaccharide (LPS) and endotoxins present on bacterial wall and many other inflammatory agents bind to a co-receptor (CD14) on the surface of specific immune cells like macrophages, resulting in their activation (J.C. Lee et al., 1996). LPS also bind to LPS-binding proteins which are produced by the liver. These proteins facilitate LPS binding to the CD14 co-receptor of the macrophages. The CD14 co-receptor is activated through the binding of LPS to a toll-like molecule (TLR4), (Re F, Strominger J. Et al., 2001) which is responsible for initiating the transmembrane signaling. TLR2 molecules act in the same way as TLR4, (Leppper PM et al., 2002) though; these are activated by gram-positive bacteria, mycobacteria and yeast. Gram-positive bacteria such as Staphylococcus aureus have further additional wall fragments such as peptidoglycan (PepG) and lipoteichoic acid (LTA). Both PepG and LTA have been shown to synergise to produce the characteristic features of septic shock, MODS and ultimately death in rodent models (S.J. De Kimpe et al., 1995 and G.M. Millar et al., 1997). These effects were not observed with either LTA or peptidoglycan alone, although high doses of LTA can cause circulatory failure but not MODS (S.J. De Kimpe et al., 1995). Gram-positive bacteria may also release other enterotoxins and exotoxins, for example toxic shock syndrome toxin 1, which are involved in the pathogenesis of sepsis (reviewed in (R.C. Bone et al., 1994)). The additional fragments released by Gram-positive bacteria bind to unknown receptors however, like LPS binding, cause the release of proinflammatory cytokines TNF-a, IL-1ß, and IFN-? (Thiemermann, 1997, Titheradge, 1999). These cytokines as well as IL-6 are often produced in response to immune stimulation of macrophages and monocytes hence also in septic shock patients. IL-1 and TNF each occur in two forms, a and ß. TNF- a and both forms of IL-1 are made by activated monocytes and macrophages, whereas TNF- ß is made by activated T lymphocytes (Review by J. Saklatvala et al., 1996). There are two receptors for both IL-1 and TNF and the two forms of each cytokine interact with the same receptors. IL-1 a and ß interact with the type 1 IL-1 receptor for signal transduction, whereas type II does not appear to transmit any signal and functions as an inhibitor of IL-1 action (J. Saklatvala et al., 1996). The two types of TNF receptor, p55 (type I) and p75 (type II) have different end effects; p75 mediates the proliferative actions of TNF- a while p55 receptor signals the inflammatory response and apoptosis (J. Saklatvala et al., 1996). Complex interactions between these different mediators produce intense pathophysiological modification, which eventually lead to diffuse tissue injury and ultimately sequential system failure (multiple organ dysfunc tion syndrome), which accounts for the majority of deaths among patients with sepsis, severe sepsis and septic shock (Beal Cerra, 1994). IL-1ß and TNF-a have a very short half life compared to IL-6 and therefore IL-6 is a very good indicator of cytokinemia. The initial studies of septic shock, showed a very strong positive correlation between IL-6 levels and fatal outcome (Casey L. Et al., 1993). NO is equally a very short lived molecule with an estimated in vivo half life of only 0.1 seconds hence again it is hard to measure its levels in order to detect the severity of cytokinemia hence the severity of sepsis or septic shock. There are several molecules that contribute to the pro and anti-inflammatory responses in septic shock (Table 4); however I shall only focus on a few due to the limited word allowance. In response to inflammatory agents in septic shock, the released cytokines (TNF-a, IL-1ß, and IFN- ?), bind to their specific receptors activating a protein kinase called tyrosine kinase leading to both the activation of the nuclear factor-kB (NF-?B) (a transcription factor) and the phosphorylation of intracellular protein (Gao et al., 2008). A precise mechanism by which these cytokines act was proposed by J. Saklatvala et al. in 1996 however this has yet to be confirmed. Nitric oxide producing cells contain I-?B which is an inhibitor of NF-?B. For the activation of NF-?B, proteolytic cleavage of I-?B from NF-?B is required which forms NF-?B. This biological change allows the activated NF-?B to translocate to the nucleus, where it binds to the promoter region of the iNOS gene inducing transcription. It has also been reported to induce other inflammatory agents, such as cytokines and leukocyte-endothelial adhesion molecules (Janssen-Heininger et al., 2000). Tyrosine kinase present inside the cell acts as a messenger molecule involved in the proteolytic cleavage of I-?B/NF-?B and hence in the activation of NF-?B and iNOS expression (Hecker M, et al., 1996). In septic shock, the translated products of iNOS mRNA subsequently assemble forming the iNOS protein which in turn causes local NO proliferation (Thiemermann, 1997). Fig 2 shows the signal transduction pathway of iNOS expression in response to inflammatory agents. The physiological role of iNOS is to enhance the formation of NO (due to iNOS activity), which in turn may contribute to either the pathophysiology of septic shock (clinbical symptoms) or the host defence (Reviewed in Gao et al., 2008). Fig 3 shows a simplified schematic of the Anti Inflammatory cascade in the context of septic shock. Excess NO produced by iNOS has been reported to both induce and inhibit NF-?B (Kalra et al., 2000; Umansky et al., 1998). In year 2000, it was proposed that low levels of NO may induce further NO production while high concentrations do the opposite exhibiting a feedback mechanisms that would oppose the over expression of genes regulated by NF-?B (Janssen-Heininger et al., 2000). In addition NO at high concentrations competes with O2 at the active site of NOS, thus providing a feedback mechanism of its own synthesis (Griscavage et al., 1995; Rengasamy Johns, 1993). Biological Synthesis of Nitric Oxide (Nitric Oxide Synthases) NOS structure and substrates for NO production: In mammals, NO is exclusively formed from the enzymatic oxidation of one terminal guanidino nitrogen of the amino acid L-arginine. When expressed in moles, this reaction utilizes 1 mol each of arginine and O2, and 1.5 mol of NADPH, yielding 1 mol of NO, 1 mol of L-citrulline and 1.5 mol of NADP (R.G. Knowles et al., 1994). The reaction sequence involves the generation of an Ng-hydroxy-L-arginine intermediate, followed by the oxidation of Ng-hydroxy-L-arginine in presence of molecular oxygen to form L-citrulline and NO (Dennis J. Stuehr et al., 1991 and R.G. Knowles et al., 1994). The enzymes that accelerate the reaction above are a family of relatively large heme proteins known as NO synthase (NOS) which resemble cytochrome P450 structurally (M. M. Chan et al., 2001 and Francois Feihl, 2001) (The general mechanism of NO production from NOS is illustrated in Fig 4). All members of this family share a similar homodimeric structure, where each monomer consists of a an oxygenase domain and a reductase domain, separated by a short amino acids (30aa) sequence for the attachment of the Ca2+-binding protein calmodulin. In addition to calmodulin attachment, enzymatic activity requires the presence of four cofactors: FAD, flavin mononucleotide (FMN), tetrahydrobiopterin (BH4), and heme (Francois Feihl, 2001). Fig 5 shows the general structure of the NOS enzymes. Nitric Oxide Synthase isoforms and their locus in the Human Body: There are three known isoforms of NOS, each the product of a different gene: neuronal NOS (nNOS or NOS-1), inducible NOS (iNOS or NOS-2), and endothelial NOS (eNOS or NOS-3). nNOS and eNOS were first described in rat cerebellum and bovine aortic endothelial cells, respectively, but their tissue distribution is far wider than suggested by their names. eNOS and nNOS are involved in regulating vascular tone (R.G. Knowles et al.,1992 and S. Moncada et al., 1991) and neurotransmission respectively, whereas iNOS is involved in the immune defence although it is expressed in many cell types following endotoxin or pro inflammatory cytokine treatment (R.G. Knowles et al., 1994). nNOS is typically expressed in skeletal muscle and myenteric plexuses. eNOS is ubiquitous in vascular endothelium, but may also be found in the kidney tubular epithelial cells, placenta (Forstermann et al., 1995), and neurons (Nathan Xie, 1994). In these tissues, the expression of nNOS and eNOS is constitutive, although it may be regulated (Michel Feron, 1997). For instance, the levels of transcript for eNOS in vascular endothelial cells is increased by shear stress (Topper et al., 1996; Uematsu et al., 1995) and exercise (Wang et al., 1997), reduced by inflammatory stimuli such as TNF-a (Nathan Xie, 1994) and variably affected by hypoxia (Le Cras et al., 1998; Toporsian et al., 2000). In the physiological state, the iNOS isoform is only present at a few locations, notably the respiratory epithelium, the gravid uterus (Nathan Xie, 1994), and perhaps the ileal mucosa (Hoffman et al., 1997). iNOS expression has been demonstrated in numerous cell types including macrophages, neutrop hils, vascular endothelial (Hoffmann et al., 1999), smooth muscle cells, endocardium, myocardium, fibroblast, mesangial cells, renal tubular epithelium (Kunz et al., 1994), neurons, hepatocytes, pancreatic islet cells and astrocytes (Nathan Xie, 1994). iNOS can be induced by a number factors including UV light; cyclic AMP-elevating agents; trauma; ozone and bacterial products described earlier (see section). On the other hand, many endogenous agents may oppose cytokine induction of iNOS. These include anti-inflammatory cytokines such as IL-10, chemokines such as monocyte chemoattractant protein-1 and growth factors such as tumor growth factor-ß (Forstermann et al., 1995). In all NOS isoforms, calmodulin binding is an absolutely vital for enzymatic activity. In the cases of eNOS and nNOS, this binding necessitates relatively high concentrations of Ca2+ (see Fig 7), in the range of 0.1-1 mM (Forstermann et al., 1995). In contrast, iNOS is able to bind calmodulin virtually independ ant of Ca2+ (Table 2). Therefore, once iNOS is expressed, NO synthesis may only be limited by the availability of substrates and cofactors (J. Stuehr, 1990). As NO produced from iNOS predominantly depends only on iNOS expression, it lasts much longer than NO formed from the other isoforms of NOS. In addition iNOS produces much higher concentrations of Ca2+ compared to the consecutive forms of NOS (Cobb et al., 1996). The production of NO by eNOS and nNOS, compared to iNOS, can be controlled relatively easily by decreasing or increasing intracellular Ca2+, whereas iNOS can only be controlled through transcription (Cobb et al., 1996). In most cell types iNOS protein levels are either very low or undetectable. However, stimulation of these cells by cytokines or growth factors, can lead to increased transcription of the iNOS gene, with subsequent production of NO. On the other hand, for the prevention of iNOS expression through endotoxins, TGF-ß (Szabo, 1995) and anti inflammatory gl ucocorticoids can be administered which lower the magnitude of vascular hyporeactivity. Glucocorticoids such as Dexamethasone inhibit iNOS activity by blocking arginine transport and inhibiting tetrahydrobiopterin biosynthesis (A.J.B. Brady et al., 1992 and Thiemermann C et al., 1993). Regulation of NO production In the normal as well as in extreme physiological states (e.g. during infection), nitric oxide is considered as one of the most important signalling molecules in vivo. It is however also highly reactive and highly diffusible due to it being a free radical (one unpaired electron) (see fig 8). It is therefore important that there is strict control and regulation of nitric oxide production. The synthesis of NO within cells can be regulated in several ways such as the cellular distribution of NOS, changes in NOS gene expression, enzymatic activation by phosphorylation and the presence of cellular inhibitors NOS activity. Intracellular distribution of NOS Nitric oxide is principally regulated through strict control over the location of NO production. The NOS isoforms can be targeted to different regions of the cell, where NO will be produced in close contact with its target proteins. The image below shows the distribution of iNOS (shown in green in image 1) and eNOS (shown in red) in a trophoblast cell. The nucleus is shown in blue. Co-localisation between iNOS and eNOS will show up as a yellow colour (Phil Dash, University of Reading). The image shows that eNOS and iNOS are fairly variably distributed inside the cell, with hardly any yellow colour suggesting very little overlap in their cellular distribution (Phil Dash, University of Reading).Although both iNOS and eNOS produce NO it is likely that their different cellular distribution will lead to NO interacting with different targets and therefore having different effects (Phil Dash, University of Reading). It is very likely that the distribution of NOS isoforms is an important mechanism for regulating when and where NO is produced. Therefore the current research on NOS mainly focuses on how endogenous signals trigger NOS transport and redistribution (Rahul S. Koti et al., 2005). Activation of NOS activity NOS enzyme synthesis is principally regulated by changes in intracellular calcium levels. The constitutive isoforms of NOS, (eNOS and nNOS) have shown to proliferate following increases in Ca2+, and therefore calmodulin levels, in the cell (Rameau et al., 2003). Additionally both nNOS and